Chromatography
MetaGene is a supplier of chromatography solutions from German manufacturer emp BIOTECH and Singapore manufacturer BioChromatographix International (BCI).
emp BIOTECH is a diverse team of expert scientists including biochemists, organic chemists, designers, engineers, researchers, technicians, business developers and more.
emp BIOTECH is dedicated to making life easier with new and innovative tools and technologies and intelligent advice through every step of product development. Quality assurance, transparent workflows and change control are standard.
BioChromatographix International (BCI) develops and manufactures Next-Generation Monolithic Chromatography media for the downstream purification of Cell & Gene Therapy.
BCI's flagship AXISFLOW™ platform is a portfolio of monolithic chromatography columns for the purification of pDNA, AAV, lentivirus, mRNA, exosomes, and virus-like particles. The inverted-flow architecture enables convective, flow-independent mass transfer.
BCI was founded in 2024 to solve a real problem in downstream processing. The team includes biopharma manufacturing veterans and scientific advisors with decades of bioprocess experience. In 2026, the company was recognised at the IMAPAC Asia Pacific Biopharma Excellence Awards for innovation in downstream processing.
Biomolecule Purification
solutions for downstream processing
SMART Chromatography™
Remove the bottleneck in your downstream process.
emp BIOTECH's SMART allows the purification of biomolecules directly from the bioreactor without first having to clarify the feed stream.
It stands for Simplified Method – Applied Radial Technology: Unlike conventional
chromatography, where the feed stream flows through the continuous packed-bed solid phase from top to bottom, SMART Chromatography™ works in the radial, horizontal plane with the cells present.
SMART Chromatography™ covered by US Patent 11,325,104.
Catalogue
Download the latest emp BIOTECH
Biomolecule Purification catalogue:
Precision Meets Innovation in Chromatography – Efficiency in Every Channel™
AXISFLOW™ portfolio is purpose-built to meet the complex demands of modern biotechnology, offering cutting-edge performance for gene therapy, vaccines, and advanced therapeutics.
Empowered by Next-Generation Polymer Technology and computational fluid dynamics.
Efficiency in every channel:
get AXISFLOW™ QA in your lab.
Key Features:
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>90% supercoiled pDNA recovery across plasmid sizes
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Yield independent of flow rate (1–20 CV/min, peer-reviewed)
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~3× lower pressure drop than established monoliths
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Peer-reviewed: Separation and Purification Technology (2026)
Scanning electron micro graph of AXISFLOW™ monolith structure used for purification of plasmids.(1)
AXISFLOW™ QA
Efficiency In Every Channel™
The BioChromatographix International (BCI) AXISFLOW™ QA is a strong anion exchange monolithic column designed for pDNA purification. Its inverted-flow architecture moves product by convection, so flow rate does not limit performance and pressure stays low.
Peer-reviewed in Separation and Purification Technology (2026): >90% supercoiled pDNA recovery across plasmid sizes, yield independent of flow rate (1–20 CV/min tested), ~3× lower pressure drop than established monoliths, impurities cleared below GMP-relevant thresholds.
(1) Figure Source: Scott Wheelwright, Eric Soon, Natalie Wong, Sze Yi Lau, Alois Jungbauer, AXISFLOW™ monoliths with inverted flow morphology and high void volume enable efficient large plasmid purification, Separation and Purification Technology, Volume 394, Part 3, 2026,
(https://www.sciencedirect.com/science/article/pii/S1383586626008257)