PRAME [EPR20330] ANTIBODY PRAME (preferentially expressed antigen in melanoma) is located on chromosome 22q11.22 and encodes a 509 amino acid protein. PRAME is an autosomal cancer-testis antigen (CTA) gene. PRAME is expressed in melanoma, various nonmelanocytic malignant neoplasms, including nonsmall cell lung cancer, breast carcinoma, renal cell carcinoma, ovarian carcinoma, leukemia, synovial sarcoma, and myxoid liposarcoma. Normal healthy tissues are not known to express PRAME except for testis, ovary, placenta, adrenals, and endometrium.
PRAME is one of the most widely studied CTAs and has been associated with the outcome and risk of metastasis. PRAME is currently being investigated as a novel immunotherapy target and diagnostic marker with ongoing clinical trials that include Hodgkin’s disease, leukemia, multiple myeloma, breast cancer, pancreatic cancer, brain cancer.
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Biocare Medical's PRAME [EPR20330] is available in Concentrated and Prediluted Monoclonal Antibody formats.